Targeted Therapy Side Effects

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Most targeted therapies affect the bone marrow so there is a risk of infection and bleeding. Many patients experience fatigue and the drugs can cause nausea or bowel upset.

The majority of side effects start in the days to weeks after starting the medication. Some may start months after starting treatment. Please report any new side effects to your doctor so they can determine if they are realted to your cancer treatment and treat appropriately.

Acalabrutinib (Calquence®)	Ibrutinib (Imbruvica®)	Idelalisib (Zydelig®)	Venetoclax (Venclexta®)	Zanubrutinib (Brukinsa®)
Most common side effects include:	Most common side effects include:	Most common side effects include:	Most common side effects include:	Most common side effects include:
Infection Upper respiratory tract infection Fatigue or weakness Bleeding Headache Diarrhea or constipation Musculoskeletal pain Hyperuricemia Nausea Vomiting Elevated liver enzymes Decrease in blood cell counts Rash Bruising	Increased lymphocyte count Diarrhea or constipation Fatigue or weakness Muscle and bone pain Nausea & vomiting Edema (swelling) Cough or difficulty breathing Rash Fever Decreased number of platelets, neutrophils and red blood cells Infections Mucositis Headache Dizziness Blurred vision or dry eyes High blood pressure Anorexia GERD Bruising & bleeding Elevated liver enzymes	Elevated liver enzymes Diarrhea Neutropenia (decreased neutrophil count) Pain Fatigue Cough Nausea & vomiting Fever Rash Infections Pneumonia Anorexia Chills Increased lymphocyte count Insomnia Headache Edema Bleeding Sore mouth	Infection (ofter upper respiratory tract, sinus, pneumonia and urinary tract) Decreasd numbers of neutrophils, red blood cells and platelets Diarrhea or constipation Nausea & vomiting Fatigue Fever Elevated level of phosphate in the blood Headache Back pain	Decreased white blood cell count Upper respiratory tract infection Decreased platelet count Muscle, bone, or joint pain Diarrhea or constipation Nausea or Vomiting Weakness Infections Headache Bleeding
Serious side effects of acalabrutinib may include: Myelosuppression Hemorrhage Serious infections Secondary malignancies Tumour lysis syndrome	Serious side effects of ibrutinib may include: Atrial fibrilation or atrial flutter Pneumonia or lung disease Myelosuppression or leukostasis (extremely elevated white blood cell count) Subdural hematoma Major bleeding events Tumour lysis syndrome Secondary malignancies Leukoencephalopathy (disorders of brain white matter)	Serious side effects of idelalisib may include: Myelosuppression (reduction in the number of blood cells) Severe diarrhea/colitis Pneumonitis and serious infections Hepatoxicity (liver damage) Severe skin reactions	Serious side effects of venetoclax may include: Myelosuppression Serious infections Secondary malignancies Tumour lysis syndrome	Serious side effects of zanubrutinib may include: Myelosuppression Hemorrhage Serious infections Secondary Malignancies Cardiac Arrhythmias Tumor Lysis Syndrome

Targeted Therapy Side Effects

Acalabrutinib (Calquence®)

Ibrutinib (Imbruvica®)

Idelalisib (Zydelig®)

Venetoclax (Venclexta®)

Zanubrutinib (Brukinsa®)

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